The Senior Global Medical Director, Gastrointestinal Cancers is a key member of the Global Commercialization Organization Medical Affairs (GCOMA) Oncology team and reports to the VP, GCO Medical Affairs, Oncology. This is a strategic role with execution responsibilities, accountable for ensuring the needs and priorities of the US (as lead region) and EUR/INT regions are represented and addressed through engagement with key partners across Jazz. Working closely with regional Medical Affairs colleagues, the Senior Global Medical Director ensures a deep understanding of customer, patient, and healthcare system needs are represented consistently across global cross-functional discussions and decision-making forums.

The role serves as a critical interface between regional Medical Affairs teams and global R&D, Global Product Development and Commercialization functions, partnering closely with US and EUR/INT colleagues to ensure regional insights and priorities are understood, communicated, and appropriately considered within the Clinical Development Team (CDT), Late Development Team (LDT), Medical Functional Matrix Team (mFMT), and governance forums including the Product Governance Committee (PGC) and Development Project Review Committee (DPRC).

Success in this role requires strong partnership with regional teams, particularly in the US, to maintain close alignment with regional medical strategies and ensure that evidence generation activities and development plans address the needs of physicians, patients, and healthcare systems across regions.

Essential Functions/Responsibilities:

• Lead the GI Cancer Global Medical functional matrix team
• Partner closely with US and EUR/INT Medical Affairs teams to understand regional customer, patient, healthcare provider, and healthcare system needs and priorities
• Represent and advocate for medical perspectives within global cross-functional teams and governance forums, including CDT, LDT, PGC, and DPRC
• Contribute Medical Affairs expertise to inform early development activities, including Target Product Profile (TPP) development, clinical trial design and lifecycle planning based on regional insights and aligned future therapeutic landscape scenarios
• Ensure regional needs and insights are appropriately considered in clinical development discussions, evidence-generation activities, and lifecycle planning
• Maintain and apply a deep understanding of the competitive landscape to inform evidence generation strategy and internal development decisions
• Lead the development, maintenance, and execution of the Integrated Evidence Generation Plan (IEGP) for Solid Tumor Oncology Product, in BTC and Gastroesophageal Cancer and other GI malignancies as assigned
• Partner effectively across Medical Affairs, Clinical Development, Regulatory Affairs, Market Access, HEOR, RWE, Commercial, and other cross-functional teams to support evidence generation and scientific exchange
• Lead and support evidence-generation activities, including investigator-sponsored studies, real-world evidence initiatives, health outcomes research, and Phase IV interventional studies, where appropriate
• Lead the development of the breast cancer medical narrative by identifying and advancing key analytic needs and informing the interpretation of pivotal trial data
• Provide Medical Affairs leadership and input into the Payor Value and Evidence Plan (GVEP)
• Lead development and execution of publication strategy and evidence dissemination plan in alignment with regional evidence needs and scientific priorities
• Support scientific communications, congress planning, advisory boards, and external engagement activities as required
• Act as a subject matter expert for internal cross-functional stakeholders

Required Knowledge, Skills, and Abilities

• A minimum of 10 years of Medical Affairs, Clinical Development, or related pharmaceutical or biotechnology industry experience is required, preferably in oncology
• Experience in GI cancers and/or HER2-targeted therapies are strongly preferred
• Demonstrated experience developing and executing evidence-generation strategies, publication plans, and external scientific engagement activities
• Strong understanding of clinical research, evidence generation, and oncology drug development
• Proven ability to influence without authority and operate effectively within complex matrix organizations
• Strong strategic thinking coupled with excellent operational execution skills
• Excellent written, verbal, presentation, and stakeholder management skills
• Ability to build productive partnerships across regions and functions and effectively represent diverse stakeholder perspectives
• Demonstrated ability to manage multiple priorities and deliver high-quality outcomes in a fast-paced environment
• Experience in the lifecycle management of oncology indications strongly desired
• Evidence of success in matrix organizations and track record of high performing behaviors, including independent critical thinking, initiative, and execution under time pressure with competing priorities
• Self-awareness and emotional intelligence as demonstrated by prior experience navigating complex matrix environments successfully

Required/Preferred Education and Licenses

• Advanced scientific or healthcare degree required (PharmD, PhD, MD, MBBS, Nurse Practitioner, PA, or equivalent)
• Experience in the delivery of oncology care preferred

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